This is really promising. As a primary care doc with great familiarity and comfort prescribing metformin all day to people with diabetes, the learning curve should not be as steep compared with Paxlovid.
With a good number of my patients in their 40's sustaining long Covid to varying degrees, including disability, I plan on acting aggressively with both Paxlovid and metformin in the future. I will at least offer it, and waiting for studies on non-overweight patients does not seem prudent, given the pleiotropic affects of metformin (anti-inflammatory, anti-thrombotic, and even antiviral in vitro).
Below is my angle from primary care, but feel free to pick at this if you think it's off in any way. I also busted out a little home made graphic so don't laugh!
Would you limit the metformin to overweight people? I believe the dosage was 500 day 1, then twice a day, then 500 am/ 1000 mg pm. It will be an off label prescription, but it’s so cheap and commonly prescribed. Thanks for the review.
This is really promising. As a primary care doc with great familiarity and comfort prescribing metformin all day to people with diabetes, the learning curve should not be as steep compared with Paxlovid.
With a good number of my patients in their 40's sustaining long Covid to varying degrees, including disability, I plan on acting aggressively with both Paxlovid and metformin in the future. I will at least offer it, and waiting for studies on non-overweight patients does not seem prudent, given the pleiotropic affects of metformin (anti-inflammatory, anti-thrombotic, and even antiviral in vitro).
Below is my angle from primary care, but feel free to pick at this if you think it's off in any way. I also busted out a little home made graphic so don't laugh!
https://mccormickmd.substack.com/p/how-to-prevent-long-covid
Thanks for a timely heads up.
Would you limit the metformin to overweight people? I believe the dosage was 500 day 1, then twice a day, then 500 am/ 1000 mg pm. It will be an off label prescription, but it’s so cheap and commonly prescribed. Thanks for the review.
Thank you! Sounds promising!
Thank you. Very nice analysis of a useful study.
One more question: for people already on metformin, but at a lower dose, would you raise it to the study protocol?
I am wondering if the Metformin and Paxlovid will become a routine thing for people that are able to get prescriptions quickly.
Super Prepint analysis, thank you! Is there any recent cohort data on where CV19 or any Subvariants hide out in the human body?