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Ryan McCormick, M.D.'s avatar

This is really promising. As a primary care doc with great familiarity and comfort prescribing metformin all day to people with diabetes, the learning curve should not be as steep compared with Paxlovid.

With a good number of my patients in their 40's sustaining long Covid to varying degrees, including disability, I plan on acting aggressively with both Paxlovid and metformin in the future. I will at least offer it, and waiting for studies on non-overweight patients does not seem prudent, given the pleiotropic affects of metformin (anti-inflammatory, anti-thrombotic, and even antiviral in vitro).

Below is my angle from primary care, but feel free to pick at this if you think it's off in any way. I also busted out a little home made graphic so don't laugh!

https://mccormickmd.substack.com/p/how-to-prevent-long-covid

Thanks for a timely heads up.

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Jan's avatar

Would you limit the metformin to overweight people? I believe the dosage was 500 day 1, then twice a day, then 500 am/ 1000 mg pm. It will be an off label prescription, but it’s so cheap and commonly prescribed. Thanks for the review.

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